Source published · Original announcementSource-link check: this original issuer URL opened the press-release list in Chrome on . The original recorded URL is retained. Exact SEC copy: UNAVAILABLE — no matching copy established in this source check.. ORION first recorded .
Follow-up research question
How did the revised analysis plan differ from the earlier plan, and what did the full results establish?
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Alnylam described changes to the statistical analysis plan, endpoint structure and study exposure, and expected topline results in late June or early July 2024. This records a changed timing statement, without assigning an invented day to either phrase.
Alnylam published HELIOS-B topline results and reported that the study met its primary and secondary endpoints. This is evidence that a readout was announced; it is not an independent review of every efficacy or safety claim.
Original announcementSource-link check: this original issuer URL opened the press-release list in Chrome on . The original recorded URL is retained. Exact SEC copy: UNAVAILABLE — no matching copy established in this source check..
Source published (published_at)
Event effective (effective_at)
ORION first seen (first_seen_at)
ORION ingested (ingested_at)
Scope
These selected company announcements preserve publication dates separately from ORION’s later recording times. Registry completion dates and follow-up research questions are separate from company announcements; this historical release does not establish current guidance or continuous monitoring.